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The major concerns for most patients cen- ter on urinary incontinence and impotence. Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer. Felix Bronner, PhD Department of BioStructure and Function, Department of Pharmacology, University of Connecticut Health Center, Farmington, CT, USA Mary C Farach-Carson, PhD Department of Biology, University of Delaware, Newark, DE, USA Janet Rubin, MD Division of Endocrinology and Metabolism, Emory University School of Medicine, Veterans Affairs Medical Center, Decatur, GA, USA British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Control Number: 2005924008 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Onlie, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency.

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